Ebselen, a Seleno-organic Antioxidant, as an Electrophile Volume 19, Number 9, September 2006, pp 1196−1204

Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis.

Ebselen, a seleno-organic compound showing glutathione peroxidase-like activity, is one of the promising synthetic antioxidants. In the present study, we investigated the antioxidant activities of ebselen using a 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated mouse skin model. Double pretreatments of mouse skin with ebselen significantly inhibited TPA-induced formation of thiobarbituric aci...

Volume 48, September 2006

Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator.

BACKGROUND AND PURPOSE It has been proposed that antioxidants and spin-trap agents may be neuroprotective after acute ischemia stroke. Although the antioxidant ebselen is currently in clinical trials, little is known about the effectiveness of ebselen, which has glutathione peroxidase-like and anti-inflammatory properties in embolic stroke models. Therefore, we determined the effects of ebselen...

Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound.

Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) is now under active investigation as a neuroprotective and anticancer agent. In the present study, the induction period method was used to investigate the antioxidant activity of ebselen in the radical polymerization of methyl methacrylate (MMA) at 70 degrees C. The reaction of ebselen with growing MMA radicals (lipid radicals) showed a k(inh) o...

2006 Fields Medals Awarded, Volume 53, Number 9

On August 22, 2006, four Fields Medals were awarded at the opening ceremonies of the International Congress of Mathematicians (ICM) in Madrid, Spain. The medalists are ANDREI OKOUNKOV, GRIGORY PERELMAN, TERENCE TAO, and WENDELIN WERNER. [Editors Note: During the award ceremony, John Ball, president of the International Mathematical Union, announced that Perelman declined to accept the Fields Me...